|
ANNEX D
GUIDELINES FOR
SELECTION OF SPECIMENS AND LABORATORY TESTS FOR PATIENTS AND
FOOD
HANDLERS BASED ON INCUBATION PERIODS AND MAJOR SIGNS AND
SYMPTOMS
|
Incubation Period |
Major
signs and symptoms |
SAMPLES TO BE ANALYZED |
|
|
|
From
patients |
From
food handlers |
Test
for |
|
1. Initial or major signs and symptoms of upper
gastrointestinal tract (nausea, vomiting)
|
|
1/2 hour
|
Epigastric pain, vomiting, excessive salivation, perspiration,
tremors, contraction of the pupils, lack of muscular
coordination
|
Blood, urine
|
|
Carbamates
|
|
< 30 minutes
|
Burning, burning pain, numbness around the lips, dizziness,
difficulty in walking, respiratory paralysis
|
Gastric lavage
|
|
Saxitoxin and other toxins producing Paralytic Molluscum
poisoning (IPM)
|
|
< 1 h
|
Nausea, vomit, strange taste or burning feeling in the mouth
|
Vomit, urine, blood, stool
|
|
Antimony, arsenic, cadmium, copper, lead, zinc, tin
|
|
< 1 h
|
Nausea, vomit, retching, diarrhea, abdominal pain
|
Vomit
|
|
Acute-onset gastroenteritis
|
|
1 to 2 h
|
Nausea, vomiting, cyanosis, headache, dizziness, dyspnea,
tremors, weakness, loss of consciousness
|
Blood
|
|
Nitrites
|
|
1 to 6 hours
(average of
2 to 4 hours)
|
Nausea, vomiting, retching, diarrhea, abdominal pain,
prostration
|
Vomit, stool
|
Nasal swab, swab of the cutaneous lesion
|
Staphylococcus aureus and its
enterotoxins, Bacillus
cereus
|
|
6 to 24 hours
|
Nausea, vomiting, diarrhea, thirst, dilated pupils, collapse,
and coma
|
Urine, blood, vomit (SGPT and SGOT enzyme tests)
|
|
Amanita phalloides (mycotoxins)
|
|
2. Initial or major signs and symptoms of the lower
gastrointestinal tract (abdominal cramps and diarrheal
diseases)
|
|
8 to 22 hours (average of 10 to 12 hours)
|
Abdominal cramps, diarrhea
|
Stool
|
Stool, rectal swab
|
Clostridium perfringens, Bacillus cereus, Streptococcus
faecalis
|
|
12 to 72 h (average of 18 to 36 hours)
|
Abdominal cramps, diarrhea, vomiting, fever, chills,
discomfort
|
Stool, rectal swab
|
Stool, rectal swab
|
Salmonella, E. coli, Arizona, Shigella
|
|
1.5 to 3 days
|
Diarrhea, fever, vomiting, abdominal pain, possible respiratory
symptoms
|
Stool
|
Stool
|
Pathogenic Escherichieae and other Enterobacteriaceae, Vibrio parahaemolyticus, Yersinia enterocolitica,
Campiloba c ter
spp., Aeromonas, Pseudomonas
aeruginosa
|
|
1 to 5 days
|
Prolonged diarrhea (rice water stools), vomiting, abdominal
pains, dehydration, collapse, acidosis
|
Stool, rectal swab
|
Stool, rectal swab
|
Vibrio cholerae
|
|
1 to 12 days
|
Prolonged diarrhea, abdominal pain, anorexia, light fever
|
Stool, intestinal biopsy
|
|
Cryptosporidium
|
|
1 to 6 weeks
|
Mucoid diarrhea (fatty stool), abdominal pain, weight loss
|
Stool
|
Stool
|
Giardia lamblia
|
|
1 to several weeks (average, 3 to 4 weeks)
|
Abdominal pain, diarrhea with mucus and blood, constipation,
headache, somnolence, ulcers. Variable: often asymptomatic
|
Stool
|
Stool
|
Entamoeba histolytica
|
|
1 to 6 h
|
Nausea, vomiting, dizziness, weakness, anorexia, weight loss,
confusion
|
Blood, urine, stool, gastric washing
|
|
Chlorinated hydrocarbons
|
|
12 to 72 h
|
Vertigo, double or blurred vision, loss of papillary reflex,
difficulty swallowing, speaking and breathing, dryness of the
mouth, weakness, respiratory paralysis
|
Blood, stool
|
|
Clostridium botulinum and its
neurotoxins
|
|
>72 h
|
Hypoesthesia, weakness in the legs, spastic paralysis,
deterioration of vision, blindness, coma
|
Urine, blood, stool, hair
|
|
Organic mercury
|
|
>72 h
|
Gastroenteritis, pain in the legs, difficulty walking, limpness
in feet and wrist
|
Tissue from gastrocnemius muscle (for biopsy)
|
|
Triorthocresyl phosphate
|
|
3. Allergic signs and symptoms (facial pruritis and/or
flushing)
|
|
<1 h
|
Headache, dizziness, nausea, vomit, peppery taste, burning in
the throat, facial flushing and swelling, stomach pains,
pruritis
|
Vomit
|
|
Histamine
|
|
<1 h
|
Hypoesthesia around the mouth, ringing in the ears, flushing,
dizziness, headache, nausea
|
Blood
|
|
Monosodium glutamate
|
|
<1 h
|
Redness, hot flashes, pruritus, abdominal pain, swelling of face
and knees
|
Blood
|
|
Niacin
|
|
4. Signs and symptoms of generalized infection (fever,
chills, malaise, prostration, pains and/or swelling of the lymph
nodes)
|
|
4 to 28 days (average term 9 days)
|
Gastroenteritis, fever, edema around eyes, sweating, muscle
pain, chills, prostration, shortness of breath
|
Serum, muscle tissue (for biopsy)
|
|
Trichinella spiralis
|
|
7 to 28 days (average 14 days)
|
Malaise, headache, fever, cough, nausea, vomiting, constipation,
abdominal pain, chills, rose spots, presence of blood in stool
|
Stool, blood, urine
|
Stool, rectal swab
|
Salmonella typhi
|
|
7 to 21 days
|
Fever, chills, sweating, malaise, headache, weight loss
|
Blood
|
|
Brucella spp.
|
|
3 to 70 days
|
Fever, headache, nausea, vomiting, abortion, meningitis,
encephalitis, sepsis
|
Blood, urine
|
|
Lysteria monocytogenes
|
|
15 to 50 days
|
Fever, discomfort, anorexia, abdominal pain, dark urine,
jaundice, pigmented feces
|
Stool, urine, blood
|
|
Viral hepatitis A
|
|
15 to 65 days
|
Fever, discomfort, anorexia, abdominal pain, dark urine,
jaundice, pigmented feces
|
Stool, urine, blood
|
|
Viral hepatitis E
|
|
10 to 13 days
|
Fever, headache, myralgia, skin rash
|
Serum (IgG and IgM), tissue from lymph node (for biopsy)
|
|
Toxoplasma gondii
|
|
8 to 14 weeks
|
Minor discomfort, weight loss
|
Stool
|
|
Taenia spp.
|
|